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Preliminary results demonstrated that the Persist-2 trial met one of the co-primary endpoints showing a statistically significant response rate in spleen volume reduction in patients with myelofibrosis treated with pacritinib compared to BAT, including the approved JAK2 inhibitor ruxolitinib. Although the Persist-2 trial did not meet the other co-primary endpoint of greater than 50 percent reduction in Total Symptom Score, the preliminary analysis approached marginal significance compared to BAT. The co-primary endpoints of the trial were the proportion of patients achieving a 35 percent

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